Part1. What is Senna Leaf Extract Powder?
Senna is a herbal purgative commonly used in the world. It has the functions of purging heat stagnation, laxative, and diuretic. It has been included in the pharmacopoeias of the United States, Britain, India, China, Europe and other countries and regions. Senna leaves are widely used clinically, such as rectal examinations in outpatient clinics, preoperative cleansing of the intestines, etc. Usually, senna leaves soaked in water are used to drink, and the diarrhea begins about 2 to 3 hours after taking it, and the diarrhea is several times , can excrete the intestinal feces cleanly. Senna leaf extract is made from the dried leaves of Cassia angustifolia V or Cassia acutifolia L, and commercial extracts are usually standardized to contain 3% and 5% of total sennosides.
Part2. Pharmacological effects
1. Antibacterial effect:
10% senna extract has obvious inhibitory effect on Escherichia coli, Proteus, Shigella, Streptococcus A and albicans. Some hydroxyanthraquinones in senna have certain antibacterial effects. The alcohol extract of senna ovale has inhibitory effect on various bacteria such as staphylococcus, diphtheria bacillus, typhoid bacillus, paratyphoid bacillus, Escherichia coli, etc., and its water extract is only effective against typhoid bacillus. Senna water infusion (1:4) has inhibitory effect on skin fungi such as Microsporum audouin and Nocardia star in test tube.
2. Hemostatic effect:
After oral administration, senna leaf powder can increase platelets and fibrinogen, shorten coagulation time, recalcification time, thromboplastin time and clot contraction time, and help to stop bleeding. The crystal fibers and calcium oxalate clusters in senna have local hemostatic effect.
3. Effects on the digestive system:
Senna leaf is a kind of laxative. Recent studies have found that this drug can not only stimulate the colonic mucosa to release PG (which is considered to be a mechanism of causing diarrhea), but also make the PG levels in the gastric body and antrum of rats significantly Increase. Senna can prevent large doses of indomethacin from damaging the gastric mucosa, probably because it can antagonize the latter's inhibitory effect on gastric mucosal cyclooxygenase (PG synthase). Since the laxative effect of PG is also a protective effect on the intestinal tract, senna has a protective effect on the gastric mucosa by stimulating the synthesis of PG, which is consistent with the laxative effect of stimulating the synthesis of PG.
4. Muscle relaxation and antispasmodic effect:
Senna has a curare-like effect, which can block acetylcholine at motor nerve endings and skeletal muscles, thereby relaxing muscles. Some hydroxyanthraquinones in senna have certain antispasmodic effect.
5. Other functions:
The seeds of Senna auricularia can lower the fasting blood sugar of dogs, and the whole plant also contains cardiac glycosides.
Part3. Market prospect
The clinical application prospect of senna leaves is broad, and it has gone beyond the scope of defecation and distension, especially for the treatment of some emergencies. Pharmacological experiments have proved that this product has the functions of antibacterial, purging, hemostasis, muscle relaxation, antispasmodic and anti-gastric mucosal damage. In addition to the diameter of the large intestine, its return diameter should also include the diameter of the liver, spleen and stomach. However, the poisonous and spicy side effects of senna are also a problem that cannot be ignored. The reason for its occurrence is not only related to the individual differences of patients, but also mainly related to the excessive dosage.
